| http://purl.uniprot.org/citations/11161217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11161217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11161217 | http://www.w3.org/2000/01/rdf-schema#comment | "Endocytic proteins such as epsin, AP180, and Hip1R (Sla2p) share a conserved modular region termed the epsin NH2-terminal homology (ENTH) domain, which plays a crucial role in clathrin-mediated endocytosis through an unknown target. Here, we demonstrate a strong affinity of the ENTH domain for phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2]. With nuclear magnetic resonance analysis of the epsin ENTH domain, we determined that a cleft formed with positively charged residues contributed to phosphoinositide binding. Overexpression of a mutant, epsin Lys76 --> Ala76, with an ENTH domain defective in phosphoinositide binding, blocked epidermal growth factor internalization in COS-7 cells. Thus, interaction between the ENTH domain and PtdIns(4,5)P2 is essential for endocytosis mediated by clathrin-coated pits."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.291.5506.1047"xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.291.5506.1047"xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Itoh T."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Itoh T."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Kigawa T."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Kigawa T."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Koshiba S."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Koshiba S."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/pages | "1047-1051"xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/pages | "1047-1051"xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/title | "Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis."xsd:string |
| http://purl.uniprot.org/citations/11161217 | http://purl.uniprot.org/core/title | "Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis."xsd:string |