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http://purl.uniprot.org/citations/11162494http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11162494http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11162494http://www.w3.org/2000/01/rdf-schema#comment"DEC1 is a basic helix-loop-helix (bHLH) protein related to Drosophila Hairy, Enhancer of split and HES, and involved in the control of proliferation and/or differentiation of chondrocytes, neurons, etc. We report here the identification and characterization of human, mouse and rat DEC2, a novel member of the DEC subfamily. DEC2 had high (97%) and moderate (52%) similarities in the bHLH region and the Orange domain with DEC1, respectively. However, DEC2, but not DEC1, had alanine and glycine-rich regions in the C-terminal half. Unlike Hairy, Enhancer of split and HES, DEC2 lacked the WRPW motif for interaction with the corepressor Groucho. The DEC2 gene was mapped to human chromosome 12p11.23-p12.1, mouse chromosome 6 G2-G3 and rat chromosome 4q43 distal-q4, where the conserved linkage homology has been identified among these species. Unlike DEC1, which was broadly expressed in many tissues, DEC2 showed a more restricted pattern of mRNA expression. The DEC subfamily proteins may play an important role in tissue development."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.2000.4133"xsd:string
http://purl.uniprot.org/citations/11162494http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.2000.4133"xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Kato Y."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Kato Y."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Matsubara K."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Matsubara K."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Matsuda Y."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Matsuda Y."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Shen M."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Shen M."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Yoshida E."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Yoshida E."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Fujimoto K."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Fujimoto K."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Honda K."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Honda K."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Noshiro M."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Noshiro M."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Shingu S."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Shingu S."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Suardita K."xsd:string
http://purl.uniprot.org/citations/11162494http://purl.uniprot.org/core/author"Suardita K."xsd:string