| http://purl.uniprot.org/citations/11162685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11162685 | http://www.w3.org/2000/01/rdf-schema#comment | "Drug metabolizing enzymes are involved in the detoxification of several drugs, environmental substances, and carcinogenic compounds, and their polymorphisms have been associated with risk for a variety of cancer. In this paper, we compared the frequency of polymorphisms in cytochrome P450-1A1 gene (CYP1A1), a phase 1 gene (oxidation, activation), and of two polymorphisms of glutathione S-transferase enzymes (GSTM1, GSTT1), two phase 2 genes (conjugation, detoxification). Two groups were studied and compared, i.e., 94 nonagenarians and centenarians and 418 control subjects of younger age. A significant difference in the proportion of nonagenarians and centenarians homozygotes for a GSTT1 deletion (28%) was observed in comparison to control subjects (19%, P = 0.03). The distribution of the other gene polymorphisms did not differ in the two groups. These findings on phase 2 drug-metabolizing enzyme gene polymorphisms may help in disentangling gene-environmental interactions which can have a role in successful aging and longevity, as well as in cancer incidence in the oldest old."xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2001.4280"xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/author | "Bertolini S."xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/author | "Monti D."xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/author | "Taioli E."xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/author | "Franceschi C."xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/author | "Marinelli D."xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/author | "Bonafe M."xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/author | "Garte S."xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/author | "Mari D."xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/pages | "1389-1392"xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/title | "Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus."xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/11162685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11162685 |
| http://purl.uniprot.org/citations/11162685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11162685 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JMS2-mappedCitation-11162685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11162685 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JQD8-mappedCitation-11162685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11162685 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JQM0-mappedCitation-11162685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11162685 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JRJ5-mappedCitation-11162685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11162685 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JRN4-mappedCitation-11162685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11162685 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JRQ5-mappedCitation-11162685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11162685 |
| http://purl.uniprot.org/uniprot/#_A0N0X8-mappedCitation-11162685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11162685 |