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http://purl.uniprot.org/citations/11163214http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11163214http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11163214http://www.w3.org/2000/01/rdf-schema#comment"A search for c-Abl interacting proteins resulted in the recovery of PSTPIP1, originally identified as a binding protein of the PEST-type protein tyrosine phosphatases (PTP). PSTPIP1 was phosphorylated by c-Abl, and growth factor-induced PSTPIP1 phosphorylation was diminished in Abl null fibroblasts. PSTPIP1 was able to bridge c-Abl to the PEST-type PTPs. Several experiments suggest that the PEST-type PTPs negatively regulate c-Abl activity: c-Abl was hyperphosphorylated in PTP-PEST-deficient cells; disruption of the c-Abl-PSTPIP1-PEST-type PTP ternary complex by overexpression of PSTPIP1 mutants increased c-Abl phosphotyrosine content; and PDGF-induced c-Abl kinase activation was prolonged in PTP-PEST-deficient cells. Dephosphorylation of c-Abl by PEST-type PTP represents a novel mechanism by which c-Abl activity is regulated."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.org/dc/terms/identifier"doi:10.1016/s1097-2765(00)00138-6"xsd:string
http://purl.uniprot.org/citations/11163214http://purl.org/dc/terms/identifier"doi:10.1016/s1097-2765(00)00138-6"xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Wu Y."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Wu Y."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Lasky L.A."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Lasky L.A."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Goff S.P."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Goff S.P."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Cong F."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Cong F."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Cote J.F."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Cote J.F."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Spencer S."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Spencer S."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Tremblay M.L."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/author"Tremblay M.L."xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/name"Mol. Cell"xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/name"Mol. Cell"xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/pages"1413-1423"xsd:string
http://purl.uniprot.org/citations/11163214http://purl.uniprot.org/core/pages"1413-1423"xsd:string