| http://purl.uniprot.org/citations/11163258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11163258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11163258 | http://www.w3.org/2000/01/rdf-schema#comment | "LIS1, a microtubule-associated protein, is required for neuronal migration, but the precise mechanism of LIS1 function is unknown. We identified a LIS1 interacting protein encoded by a mouse homolog of NUDE, a nuclear distribution gene in A. nidulans and a multicopy suppressor of the LIS1 homolog, NUDF. mNudE is located in the centrosome or microtubule organizing center (MTOC), and interacts with six different centrosomal proteins. Overexpression of mNudE dissociates gamma-tubulin from the centrosome and disrupts microtubule organization. Missense mutations that disrupt LIS1 function block LIS1-mNudE binding. Moreover, misexpression of the LIS1 binding domain of mNudE in Xenopus embryos disrupts the architecture and lamination of the CNS. Thus, LIS1-mNudE interactions may regulate neuronal migration through dynamic reorganization of the MTOC."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(00)00145-8"xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(00)00145-8"xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Kirschner M.W."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Kirschner M.W."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Walsh C.A."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Walsh C.A."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Stukenberg P.T."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Stukenberg P.T."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Flanagan L.A."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Flanagan L.A."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Olson E.C."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/author | "Olson E.C."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/pages | "665-679"xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/pages | "665-679"xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/title | "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome."xsd:string |
| http://purl.uniprot.org/citations/11163258 | http://purl.uniprot.org/core/title | "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome."xsd:string |