http://purl.uniprot.org/citations/11163272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11163272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11163272 | http://www.w3.org/2000/01/rdf-schema#comment | "Photoreceptor cells utilize ribbon synapses to transmit sensory signals at high resolution. Ribbon synapses release neurotransmitters tonically, with a high release rate made possible by continuous docking of synaptic vesicles on presynaptic ribbons. We have partially purified synaptic ribbons from retina and identified a major protein component called RIBEYE. RIBEYE is composed of a unique A domain specific for ribbons, and a B domain identical with CtBP2, a transcriptional repressor that in turn is related to 2-hydroxyacid dehydrogenases. The A domain mediates assembly of RIBEYE into large structures, whereas the B domain binds NAD(+) with high affinity, similar to 2-hydroxyacid dehydrogenases. Our results define a unique component of synaptic ribbons and suggest that RIBEYE evolved in vertebrates under utilization of a preexisting protein to build a unique scaffold for a specialized synapse."xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(00)00159-8"xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(00)00159-8"xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/author | "Schmitz F."xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/author | "Schmitz F."xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/author | "Koenigstorfer A."xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/author | "Koenigstorfer A."xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/pages | "857-872"xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/pages | "857-872"xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/title | "RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function."xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/title | "RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function."xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/volume | "28"xsd:string |
http://purl.uniprot.org/citations/11163272 | http://purl.uniprot.org/core/volume | "28"xsd:string |
http://purl.uniprot.org/citations/11163272 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11163272 |
http://purl.uniprot.org/citations/11163272 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11163272 |
http://purl.uniprot.org/citations/11163272 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11163272 |
http://purl.uniprot.org/citations/11163272 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11163272 |