| http://purl.uniprot.org/citations/11163544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11163544 | http://www.w3.org/2000/01/rdf-schema#comment | "The affinity of clozapine for 5-HT2A, 5-HT2C, 5-HT6, 5-HT7, and 5-HT1A receptors has been suggested to contribute to various aspects of its complex clinical actions. This study examined the hypothesis that genetic variation in 5-HT1A, 5-HT6, and 5-HT7 receptor genes is involved in the variability observed in response to clozapine. We employed a pharmacogenetic approach in a group (n=185) of schizophrenia patients that have been clinically well characterized for clozapine response. Polymorphisms in the 5-HT6 (HTR6), 5-HT1A (HTR1A) and 5-HT7 (HTR7) receptor genes were genotyped. No evidence for either an allelic or genotypic association of the T-->C 267 HTR6 polymorphism with response to clozapine was found in our sample (allele: chi(2)=0.06, 1 df, P=0.80; genotype: chi(2)=1.21, 2 df, P=0.55). The pro16leu HTR1A polymorphism was not observed in our sample; all individuals genotyped were pro/pro 16 homozygotes. With respect to the pro279leu HTR7 polymorphism, one Caucasian male responder to clozapine was observed to be heterozygous (pro/leu 279 genotype). This individual was clinically similar to the other clozapine responders. Overall, our findings do not support a role for the T-->C 267 polymorphism of the 5-HT6 receptor gene in response to clozapine, although replication is required to confirm this finding."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0920-9964(00)00016-5"xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/author | "Hamblin M.W."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/author | "Kennedy J.L."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/author | "Lieberman J.A."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/author | "Goldman D.A."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/author | "Macciardi F.M."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/author | "Meltzer H.Y."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/author | "Basile V.S."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/author | "Masellis M."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/author | "Sevy S."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/name | "Schizophr Res"xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/pages | "49-58"xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/title | "Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia."xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/11163544 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11163544 |
| http://purl.uniprot.org/citations/11163544 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11163544 |
| http://purl.uniprot.org/uniprot/#_A0N5V3-mappedCitation-11163544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11163544 |
| http://purl.uniprot.org/uniprot/#_A8K5W4-mappedCitation-11163544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11163544 |
| http://purl.uniprot.org/uniprot/#_P50406-mappedCitation-11163544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11163544 |
| http://purl.uniprot.org/uniprot/#_P08908-mappedCitation-11163544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11163544 |
| http://purl.uniprot.org/uniprot/#_P34969-mappedCitation-11163544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11163544 |
| http://purl.uniprot.org/uniprot/#_Q59GI0-mappedCitation-11163544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11163544 |