| http://purl.uniprot.org/citations/11168809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11168809 | http://www.w3.org/2000/01/rdf-schema#comment | "Scleroderma is a disorder characterized by fibrosis of the skin and internal organs and autoimmunity. Whereas the cause is unknown, interleukin-4 and transforming growth factor-beta have been postulated to play a major part in the fibrosis. To investigate the part played by these cytokines, we prepared TSK/+ mice with a targeted mutation in the interleukin-4R alpha or transforming growth factor-beta genes. The breeding failed to produce TSK/+ transforming growth factor-beta -/-mice so analysis of the role of transforming growth factor-beta was limited to TSK/+ transforming growth factor-beta +/-mice. We observed that TSK/+ interleukin-4R alpha -/-did not develop dermal thickening, and deletion of one allele of the transforming growth factor-beta gene resulted in diminished dermal thickness compared with TSK/+ mice; however, the deletion of interleukin-4R alpha or transforming growth factor-beta had no effect on lung emphysema, which is another characteristic of TSK syndrome. Electron microscopic analysis of skin showed that the collagen fibrils in TSK/+ interleukin-4R alpha -/-mice exhibit normal periodicity but have a smaller diameter than the fibers found in C57BL/6 mice. Analysis of skin and serum samples showed that the deletion of interleukin-4R alpha or one allele of transforming growth factor-beta prevented the increase of skin thickness paralleled with a decrease in the dermal hydroxyproline content and development of autoantibodies associated with TSK syndrome. These results demonstrate the importance of interleukin-4 and transforming growth factor-beta for the development of cutaneous fibrosis in vivo and suggest an important part for these cytokines in wound healing and connective tissue maintenance in general."xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1523-1747.2001.00217.x"xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/author | "Saito S."xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/author | "Gordon R."xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/author | "Phelps R.G."xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/author | "Paul W.E."xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/author | "Bona C."xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/author | "Noben-Trauth N."xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/author | "McGaha T."xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/pages | "136-143"xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/title | "Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes."xsd:string |
| http://purl.uniprot.org/citations/11168809 | http://purl.uniprot.org/core/volume | "116"xsd:string |
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