| http://purl.uniprot.org/citations/11169254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11169254 | http://www.w3.org/2000/01/rdf-schema#comment | "Soluble HLA-G (sHLA-G) molecules are found in the peripheral blood of healthy females and males, in cord blood and in amniotic fluids and discussed to be a mediator in maternal-fetal tolerance. In this study we investigated whether there are allele-specific differences in expression of sHLA-G molecules. For this, the sHLA-G plasma concentrations of 94 healthy unrelated individuals were measured by ELISA and correlated to their HLA-G genotypes, as determined by sequence analysis of exon 2 and 3 of the HLA-G gene. Mean sHLA-G levels in individuals with the most common HLA-G alleles G*01011 (27.0+/-2.1 SEM ng/ml, n=66), G*01012 (28.4+/-3.2 SEM ng/ml, n=34) were very similar. In contrast, individuals carrying the HLA-G*01013 (8.1+/-1.7 SEM ng/ml, n=17) or the "null" allele HLA-G*0105N (8.2+/-3.2 SEM ng/ml, n=7) presented significantly (P(c)=0.001 and P(c)<0.01, resp.) reduced sHLA-G levels. Furthermore, individuals with the HLA-G*01041 allele had significantly (P(c)=0.004) increased sHLA-G levels (42.5+/-4.6 SEM ng/ml, n=14). These results demonstrate that the generation of sHLA-G molecules is associated to certain HLA-G alleles and imply that sHLA-G levels are under genetic control. As low and high sHLA-G plasma levels did not segregate with HLA haplotypes including the HLA-G*01013 or *01041 allele, additional mechanisms may be involved in the regulation of the individual sHLA-G levels. Nevertheless, the existence of "low" and "high secretor" HLA-G alleles further suggests different levels of functionality in immune regulation."xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.org/dc/terms/identifier | "doi:10.1034/j.1399-0039.2001.057001015.x"xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/author | "Pfeiffer K."xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/author | "van der Ven K."xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/author | "Grosse-Wilde H."xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/author | "Rebmann V."xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/author | "Krebs D."xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/author | "Passler M."xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/pages | "15-21"xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/title | "Association of soluble HLA-G plasma levels with HLA-G alleles."xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/11169254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11169254 |
| http://purl.uniprot.org/citations/11169254 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11169254 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9X9-mappedCitation-11169254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11169254 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y0-mappedCitation-11169254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11169254 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y1-mappedCitation-11169254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11169254 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y2-mappedCitation-11169254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11169254 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y3-mappedCitation-11169254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11169254 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y6-mappedCitation-11169254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11169254 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Z1-mappedCitation-11169254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11169254 |
| http://purl.uniprot.org/uniprot/#_A0A0H4LTX5-mappedCitation-11169254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11169254 |
| http://purl.uniprot.org/uniprot/#_A0A0H4LTX9-mappedCitation-11169254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11169254 |