| http://purl.uniprot.org/citations/11171341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11171341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11171341 | http://www.w3.org/2000/01/rdf-schema#comment | "In Caenorhabditis elegans, Wnt signaling pathways are important in controlling cell polarity and cell migrations. In the embryo, a novel Wnt pathway functions through a (beta)-catenin homolog, WRM-1, to downregulate the levels of POP-1/Tcf in the posterior daughter of the EMS blastomere. The level of POP-1 is also lower in the posterior daughters of many anteroposterior asymmetric cell divisions during development. I have found that this is the case for of a pair of postembryonic blast cells in the tail. In wild-type animals, the level of POP-1 is lower in the posterior daughters of the two T cells, TL and TR. Furthermore, in lin-44/Wnt mutants, in which the polarities of the T cell divisions are frequently reversed, the level of POP-1 is frequently lower in the anterior daughters of the T cells. I have used a novel RNA-mediated interference technique to interfere specifically with pop-1 zygotic function and have determined that pop-1 is required for wild-type T cell polarity. Surprisingly, none of the three C. elegans (beta)-catenin homologs appeared to function with POP-1 to control T cell polarity. Wnt signaling by EGL-20/Wnt controls the migration of the descendants of the QL neuroblast by regulating the expression the Hox gene mab-5. Interfering with pop-1 zygotic function caused defects in the migration of the QL descendants that mimicked the defects in egl-20/Wnt mutants and blocked the expression of mab-5. This suggests that POP-1 functions in the canonical Wnt pathway to control QL descendant migration and in novel Wnt pathways to control EMS and T cell polarities."xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.128.4.581"xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.128.4.581"xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/author | "Herman M."xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/author | "Herman M."xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/pages | "581-590"xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/pages | "581-590"xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/title | "C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity."xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/title | "C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity."xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/11171341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11171341 |
| http://purl.uniprot.org/citations/11171341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11171341 |
| http://purl.uniprot.org/citations/11171341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11171341 |
| http://purl.uniprot.org/citations/11171341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11171341 |
| http://purl.uniprot.org/uniprot/Q27886 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11171341 |
| http://purl.uniprot.org/uniprot/Q27886#attribution-3F109B7954E7A6BCE920F6BC219110EB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11171341 |
| http://purl.uniprot.org/uniprot/#_Q27886-citation-11171341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11171341 |
| http://purl.uniprot.org/uniprot/#_A0A078BS14-mappedCitation-11171341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11171341 |