| http://purl.uniprot.org/citations/11171603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11171603 | http://www.w3.org/2000/01/rdf-schema#comment | "During lactation, branched-chain aminotransferase (BCAT) gene expression increases in the mammary gland. To determine the cell type and whether this induction is present only during lactation, female rats were randomly assigned to one of three experimental groups: pregnancy, lactation, or postweaning. Mammary gland BCAT activity during the first days of pregnancy was similar to that of virgin rats, increasing significantly from day 16 to the last day of pregnancy. Maximal BCAT activity occurred on day 12 of lactation. During postweaning, BCAT activity decreased rapidly to values close to those observed in virgin rats. Analyses by Western and Northern blot revealed that changes in enzyme activity were accompanied by parallel changes in the amount of enzyme and its mRNA. Immunohistochemical studies of the mammary gland showed a progressive increase in mitochondrial BCAT (mBCAT)-specific staining of the epithelial acinar cells during lactation, reaching high levels by day 12. Immunoreactivity decreased rapidly after weaning. There was a significant correlation between total BCAT activity and milk production. These results indicate that the pattern of mBCAT gene expression follows lactogenesis stages I and II and is restricted to the milk-producing epithelial acinar cells. Furthermore, BCAT activity is associated with milk production in the mammary gland during lactation."xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpendo.2001.280.3.e480"xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/author | "Lopez G."xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/author | "Hutson S.M."xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/author | "Hernandez-Pando R."xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/author | "Torres N."xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/author | "Becerril E."xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/author | "Desantiago S."xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/author | "Suryawan A."xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/author | "Tovar A.R."xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/name | "Am J Physiol Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/pages | "E480-8"xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/title | "Localization and expression of BCAT during pregnancy and lactation in the rat mammary gland."xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/11171603 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11171603 |
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