http://purl.uniprot.org/citations/11171996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11171996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11171996 | http://www.w3.org/2000/01/rdf-schema#comment | "To better understand the structure and function of Z lines, we used sarcomeric isoforms of alpha-actinin and gamma-filamin to screen a human skeletal muscle cDNA library for interacting proteins by using the yeast two-hybrid system. Here we describe myozenin (MYOZ), an alpha-actinin- and gamma-filamin-binding Z line protein expressed predominantly in skeletal muscle. Myozenin is predicted to be a 32-kDa, globular protein with a central glycine-rich domain flanked by alpha-helical regions with no strong homologies to any known genes. The MYOZ gene has six exons and maps to human chromosome 10q22.1-q22.2. Northern blot analysis demonstrated that this transcript is expressed primarily in skeletal muscle with significantly lower levels of expression in several other tissues. Antimyozenin antisera stain skeletal muscle in a sarcomeric pattern indistinguishable from that seen by using antibodies for alpha-actinin, and immunogold electron microscopy confirms localization specifically to Z lines. Thus, myozenin is a skeletal muscle Z line protein that may be a good candidate gene for limb-girdle muscular dystrophy or other neuromuscular disorders."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.98.4.1595"xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.98.4.1595"xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Beggs A.H."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Beggs A.H."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Kunkel L.M."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Kunkel L.M."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Takada F."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Takada F."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Thompson T.G."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Thompson T.G."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Tong H.-Q."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Tong H.-Q."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Vander Woude D.L."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Vander Woude D.L."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Watkins S.C."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/author | "Watkins S.C."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/pages | "1595-1600"xsd:string |
http://purl.uniprot.org/citations/11171996 | http://purl.uniprot.org/core/pages | "1595-1600"xsd:string |