| http://purl.uniprot.org/citations/11172710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11172710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11172710 | http://www.w3.org/2000/01/rdf-schema#comment | "Polymerase gamma, which replicates and repairs mitochondrial DNA, requires the Pol gamma B subunit for processivity. We determined the crystal structure of mouse Pol gamma B, a core component of the mitochondrial replication machinery. Pol gamma B shows high similarity to glycyl-tRNA synthetase and dimerizes through an unusual intermolecular four-helix bundle. A human Pol gamma B mutant lacking the four-helix bundle failed to dimerize in solution or to stimulate the catalytic subunit Pol gamma A, but retained the ability to bind with Pol gamma A to a primer-template construct, indicating that the functional holoenzyme contains two Pol gamma B molecules. Other mutants retained stimulatory activity but lost the ability to bind folded ssDNA. These results suggest that the Pol gamma B dimer contains distinct sites for Pol gamma A binding, dimerization, and DNA binding."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00153-8"xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00153-8"xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/author | "Kisker C."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/author | "Kisker C."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/author | "Theis K."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/author | "Theis K."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/author | "Bogenhagen D.F."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/author | "Bogenhagen D.F."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/author | "Carrodeguas J.A."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/author | "Carrodeguas J.A."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/pages | "43-54"xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/pages | "43-54"xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/title | "Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/title | "Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer."xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/11172710 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11172710 |
| http://purl.uniprot.org/citations/11172710 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11172710 |