| http://purl.uniprot.org/citations/11175787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11175787 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling enzymes that have been implicated in the regulation of gene expression, cell-cycle control and oncogenesis. MyoD is a muscle-specific regulator able to induce myogenesis in numerous cell types. To ascertain the requirement for chromatin remodeling enzymes in cellular differentiation processes, we examined MyoD-mediated induction of muscle differentiation in fibroblasts expressing dominant-negative versions of the human brahma-related gene-1 (BRG1) or human brahma (BRM), the ATPase subunits of two distinct SWI/SNF enzymes. We find that induction of the myogenic phenotype is completely abrogated in the presence of the mutant enzymes. We further demonstrate that failure to induce muscle-specific gene expression correlates with inhibition of chromatin remodeling in the promoter region of an endogenous muscle-specific gene. Our results demonstrate that SWI/SNF enzymes promote MyoD-mediated muscle differentiation and indicate that these enzymes function by altering chromatin structure in promoter regions of endogenous, differentiation-specific loci."xsd:string |
| http://purl.uniprot.org/citations/11175787 | http://purl.org/dc/terms/identifier | "doi:10.1038/84826"xsd:string |
| http://purl.uniprot.org/citations/11175787 | http://purl.uniprot.org/core/author | "Carlson K.A."xsd:string |
| http://purl.uniprot.org/citations/11175787 | http://purl.uniprot.org/core/author | "Imbalzano A.N."xsd:string |
| http://purl.uniprot.org/citations/11175787 | http://purl.uniprot.org/core/author | "de la Serna I.L."xsd:string |
| http://purl.uniprot.org/citations/11175787 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11175787 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/11175787 | http://purl.uniprot.org/core/pages | "187-190"xsd:string |
| http://purl.uniprot.org/citations/11175787 | http://purl.uniprot.org/core/title | "Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation."xsd:string |
| http://purl.uniprot.org/citations/11175787 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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