| http://purl.uniprot.org/citations/11178875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11178875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11178875 | http://www.w3.org/2000/01/rdf-schema#comment | "The Shank family of proteins (also termed CortBP, ProSAP, or Synamon) is highly enriched in the postsynaptic density (PSD) of excitatory synapses in brain. Shank contains multiple domains for protein-protein interactions, including ankyrin repeats, SH3 domain, PDZ domain, SAM domain, and an extensive proline-rich region. We have identified a novel protein, termed Sharpin, that directly interacts with the ankyrin repeats of Shank. Sharpin is enriched in the PSD and forms a complex with Shank in heterologous cells and brain. Immunostaining reveals the presence of Sharpin at excitatory synapses and its colocalization with Shank. While the C-terminal half of Sharpin interacts with Shank, the N-terminal half of Sharpin mediates homomultimerization. Considering the fact that the ankyrin repeats and the SH3 domain of Shank can be truncated by alternative splicing, these results define Sharpin as a novel PSD protein that may regulate the complexity of the Shank-based protein network in an alternative splicing-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.org/dc/terms/identifier | "doi:10.1006/mcne.2000.0940"xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.org/dc/terms/identifier | "doi:10.1006/mcne.2000.0940"xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Kuroda S."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Kuroda S."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Lim S."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Lim S."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Sala C."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Sala C."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Yoon J."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Yoon J."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Sheng M."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/author | "Sheng M."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/name | "Mol. Cell. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/name | "Mol. Cell. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/pages | "385-397"xsd:string |
| http://purl.uniprot.org/citations/11178875 | http://purl.uniprot.org/core/pages | "385-397"xsd:string |