| http://purl.uniprot.org/citations/11179424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11179424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11179424 | http://www.w3.org/2000/01/rdf-schema#comment | "The Schizosaccharomyces pombe stress-activated Sty1p/Spc1p mitogen-activated protein (MAP) kinase regulates gene expression through the Atf1p and Pap1p transcription factors, homologs of human ATF2 and c-Jun, respectively. Mcs4p, a response regulator protein, acts upstream of Sty1p by binding the Wak1p/Wis4p MAP kinase kinase kinase. We show that phosphorylation of Mcs4p on a conserved aspartic acid residue is required for activation of Sty1p only in response to peroxide stress. Mcs4p acts in a conserved phospho-relay system initiated by two PAS/PAC domain-containing histidine kinases, Mak2p and Mak3p. In the absence of Mak2p or Mak3p, Sty1p fails to phosphorylate the Atf1p transcription factor or induce Atf1p-dependent gene expression. As a consequence, cells lacking Mak2p and Mak3p are sensitive to peroxide attack in the absence of Prr1p, a distinct response regulator protein that functions in association with Pap1p. The Mak1p histidine kinase, which also contains PAS/PAC repeats, does not regulate Sty1p or Atf1p but is partially required for Pap1p- and Prr1p-dependent transcription. We conclude that the transcriptional response to free radical attack is initiated by at least two distinct phospho-relay pathways in fission yeast."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.12.2.407"xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.12.2.407"xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Makino K."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Makino K."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Martin H."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Martin H."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Quinn J."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Quinn J."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Morgan B.A."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Morgan B.A."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Buck V."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Buck V."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Millar J.B.A."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Millar J.B.A."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Saldanha J."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Saldanha J."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Soto Pino T."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/author | "Soto Pino T."xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11179424 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |