| http://purl.uniprot.org/citations/11179500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11179500 | http://www.w3.org/2000/01/rdf-schema#comment | "Bcl-2 family member proteins are differentially expressed in skin and in non-melanoma skin cancer (NMSC). To elucidate the contribution of bcl-2 and bax proteins to epidermal differentiation and skin carcinogenesis, we investigated keratinocyte proliferation, differentiation and tumourigenesis in bcl-2(-/-) and bax(-/-) mice. The rate and pattern of proliferation and spontaneous cell death in the bcl-2(-/-) and bax(-/-) mice were not different from control mice. The epidermis of bcl-2(-/-) and bax(-/-) expressed sightly higher levels of cytokeratin 1 and loricrin compared to control littermates. The apoptotic response to ultraviolet-induced genotoxic stress was assessed by quantitating TUNEL positive cells. Bax(-/-) keratinocytes showed a significant resistance to UV-induced cell death compared to control mice. The life-span of bcl-2(-/-) mice precluded an assessment of bcl-2 gene disruption on in vivo tumourigenesis. A significant increase in tumour incidence was observed in bax(-/-) mice compared to control mice in two-step chemical carcinogenesis studies. These findings suggest that bcl-2 and bax gene products may be important determinants of normal keratinocyte differentiation and response to genotoxic stress in vivo, and indicate that bax may provide a tumour suppressor effect during skin carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/11179500 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijmm.7.3.235"xsd:string |
| http://purl.uniprot.org/citations/11179500 | http://purl.uniprot.org/core/author | "Cho S.H."xsd:string |
| http://purl.uniprot.org/citations/11179500 | http://purl.uniprot.org/core/author | "Delehedde M."xsd:string |
| http://purl.uniprot.org/citations/11179500 | http://purl.uniprot.org/core/author | "McDonnell T.J."xsd:string |
| http://purl.uniprot.org/citations/11179500 | http://purl.uniprot.org/core/author | "Rodriguez-Villanueva J."xsd:string |
| http://purl.uniprot.org/citations/11179500 | http://purl.uniprot.org/core/author | "Brisbay S."xsd:string |
| http://purl.uniprot.org/citations/11179500 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11179500 | http://purl.uniprot.org/core/name | "Int J Mol Med"xsd:string |
| http://purl.uniprot.org/citations/11179500 | http://purl.uniprot.org/core/pages | "235-241"xsd:string |
| http://purl.uniprot.org/citations/11179500 | http://purl.uniprot.org/core/title | "Bax gene disruption alters the epidermal response to ultraviolet irradiation and in vivo induced skin carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/11179500 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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