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http://purl.uniprot.org/citations/11196647http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11196647http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11196647http://www.w3.org/2000/01/rdf-schema#comment"With the availability of complete DNA sequences for many prokaryotic and eukaryotic genomes, and soon for the human genome itself, it is important to develop reliable proteome-wide approaches for a better understanding of protein function. As elementary constituents of cellular protein complexes and pathways, protein-protein interactions are key determinants of protein function. Here we have built a large-scale protein-protein interaction map of the human gastric pathogen Helicobacter pylori. We have used a high-throughput strategy of the yeast two-hybrid assay to screen 261 H. pylori proteins against a highly complex library of genome-encoded polypeptides. Over 1,200 interactions were identified between H. pylori proteins, connecting 46.6% of the proteome. The determination of a reliability score for every single protein-protein interaction and the identification of the actual interacting domains permitted the assignment of unannotated proteins to biological pathways."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.org/dc/terms/identifier"doi:10.1038/35051615"xsd:string
http://purl.uniprot.org/citations/11196647http://purl.org/dc/terms/identifier"doi:10.1038/35051615"xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Schaechter V."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Schaechter V."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Simon S."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Simon S."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Labigne A."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Labigne A."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"De Reuse H."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"De Reuse H."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Battaglia V."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Battaglia V."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Chemama Y."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Chemama Y."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Legrain P."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Legrain P."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Lenzen G."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Lenzen G."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Petel F."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Petel F."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Rain J.-C."xsd:string
http://purl.uniprot.org/citations/11196647http://purl.uniprot.org/core/author"Rain J.-C."xsd:string