| http://purl.uniprot.org/citations/11201732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11201732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11201732 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.org/dc/terms/identifier | "doi:10.1038/35053000"xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.org/dc/terms/identifier | "doi:10.1038/35053000"xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Bhat S."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Bhat S."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Brown E.J."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Brown E.J."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Bailey S.T."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Bailey S.T."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Patel H.R."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Patel H.R."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Lazar M.A."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Lazar M.A."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Ahima R.S."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Ahima R.S."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Wright C.M."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Wright C.M."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Steppan C.M."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Steppan C.M."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Banerjee R.R."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/author | "Banerjee R.R."xsd:string |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11201732 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |