| http://purl.uniprot.org/citations/11207362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11207362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11207362 | http://www.w3.org/2000/01/rdf-schema#comment | "Chloride channels play important roles in the plasma membrane and in intracellular organelles. Mice deficient for the ubiquitously expressed ClC-7 Cl(-) channel show severe osteopetrosis and retinal degeneration. Although osteoclasts are present in normal numbers, they fail to resorb bone because they cannot acidify the extracellular resorption lacuna. ClC-7 resides in late endosomal and lysosomal compartments. In osteoclasts, it is highly expressed in the ruffled membrane, formed by the fusion of H(+)-ATPase-containing vesicles, that secretes protons into the lacuna. We also identified CLCN7 mutations in a patient with human infantile malignant osteopetrosis. We conclude that ClC-7 provides the chloride conductance required for an efficient proton pumping by the H(+)-ATPase of the osteoclast ruffled membrane."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00206-9"xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00206-9"xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Schweizer M."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Schweizer M."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Schulz A."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Schulz A."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Jentsch T.J."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Jentsch T.J."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Boesl M.R."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Boesl M.R."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Kornak U."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Kornak U."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Delling G."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Delling G."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Kaiser E."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Kaiser E."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Kasper D."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Kasper D."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Friedrich W."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/author | "Friedrich W."xsd:string |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11207362 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |