| http://purl.uniprot.org/citations/11213599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11213599 | http://www.w3.org/2000/01/rdf-schema#comment | "AimThe beta 3-adrenergic receptor (beta 3-AR) is suspected to play a key role in the regulation of energy balance by increasing lipolysis and thermogenesis. A mutation in the beta 3-AR gene (Trp64Arg) has been associated with the capacity of weight gain and with early onset of noninsulin dependent diabetes mellitus (type 2 diabetes). In this study we investigated the prevalence of the two beta 3-AR alleles in a Caucasian population and studied the association between the beta 3-AR genotype and metabolic disorders (obesity and type 2 diabetes).MethodsGenomic DNA extracted from peripheral blood leucocytes of 200 Caucasian subjects (137 subjects with and 63 subjects without type 2 diabetes). The MvaI polymorphism of beta 3-AR, which detects the Trp64Arg mutation, was determined by polymerase chain reaction (PCR). We studied the correlation between the Trp64Arg mutation and the body mass index (b.m.i. kg/m2).ResultsThere was no significant difference between the patients with type 2 diabetes and control subjects in the frequency of the Arg64 allele (5.5% and 4.8%, respectively). Within the group of type 2 diabetes patients were 14 subjects with the Trp64Arg mutation (b.m.i., mean +/- s.d.: 31 +/-8.5 kg/m2) and 123 without the mutation (b.m.i. 29 +/-4.8). There was no association between the beta 3-AR gene polymorphism and sex, obesity, blood pressure, glycohaemoglobin concentration, proteinuria.ConclusionOur results suggest that the Trp64Arg mutation is not a major determinant of metabolic disorders (type 2 diabetes, obesity) and chronic complications of type 2 diabetes in a Dutch population."xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1463-1326.2001.00121.x"xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://purl.uniprot.org/core/author | "Vermes I."xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://purl.uniprot.org/core/author | "Bon M.A."xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://purl.uniprot.org/core/author | "Oeveren van-Dybicz A.M."xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://purl.uniprot.org/core/author | "Vonkeman H.E."xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://purl.uniprot.org/core/author | "van den Bergh F.A."xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11213599 | http://purl.uniprot.org/core/name | "Diabetes Obes Metab"xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://purl.uniprot.org/core/pages | "47-51"xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://purl.uniprot.org/core/title | "Beta 3-adrenergic receptor gene polymorphism and type 2 diabetes in a Caucasian population."xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/11213599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11213599 |
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