| http://purl.uniprot.org/citations/11214310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11214310 | http://www.w3.org/2000/01/rdf-schema#comment | "SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) and Rab-GTPases, together with their cofactors, mediate the attachment step in the membrane fusion of vesicles. But how bilayer mixing--the subsequent core process of fusion--is catalysed remains unclear. Ca2+/calmodulin controls this terminal process in many intracellular fusion events. Here we identify V0, the membrane-integral sector of the vacuolar H+-ATPase, as a target of calmodulin on yeast vacuoles. Between docking and bilayer fusion, V0 sectors from opposing membranes form complexes. V0 trans-complex formation occurs downstream from trans-SNARE pairing, and depends on both the Rab-GTPase Ypt7 and calmodulin. The maintenance of existing complexes and completion of fusion are independent of trans-SNARE pairs. Reconstituted proteolipids form sealed channels, which can expand to form aqueous pores in a Ca2+/calmodulin-dependent fashion. V0 trans-complexes may therefore form a continuous, proteolipid-lined channel at the fusion site. We propose that radial expansion of such a protein pore may be a mechanism for intracellular membrane fusion."xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.org/dc/terms/identifier | "doi:10.1038/35054500"xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/author | "Andersen J.S."xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/author | "Peters C."xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/author | "Mayer A."xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/author | "Buhler S."xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/author | "Bayer M.J."xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/pages | "581-588"xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/title | "Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion."xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://purl.uniprot.org/core/volume | "409"xsd:string |
| http://purl.uniprot.org/citations/11214310 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11214310 |
| http://purl.uniprot.org/citations/11214310 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11214310 |
| http://purl.uniprot.org/uniprot/#_P06787-mappedCitation-11214310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11214310 |
| http://purl.uniprot.org/uniprot/#_P25515-mappedCitation-11214310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11214310 |
| http://purl.uniprot.org/uniprot/P06787 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11214310 |
| http://purl.uniprot.org/uniprot/P25515 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11214310 |