| http://purl.uniprot.org/citations/11214325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11214325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11214325 | http://www.w3.org/2000/01/rdf-schema#comment | "The transfer of DNA across membranes and between cells is a central biological process; however, its molecular mechanism remains unknown. In prokaryotes, trans-membrane passage by bacterial conjugation, is the main route for horizontal gene transfer. It is the means for rapid acquisition of new genetic information, including antibiotic resistance by pathogens. Trans-kingdom gene transfer from bacteria to plants or fungi and even bacterial sporulation are special cases of conjugation. An integral membrane DNA-binding protein, called TrwB in the Escherichia coli R388 conjugative system, is essential for the conjugation process. This large multimeric protein is responsible for recruiting the relaxosome DNA-protein complex, and participates in the transfer of a single DNA strand during cell mating. Here we report the three-dimensional structure of a soluble variant of TrwB. The molecule consists of two domains: a nucleotide-binding domain of alpha/beta topology, reminiscent of RecA and DNA ring helicases, and an all-alpha domain. Six equivalent protein monomers associate to form an almost spherical quaternary structure that is strikingly similar to F1-ATPase. A central channel, 20 A in width, traverses the hexamer."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.org/dc/terms/identifier | "doi:10.1038/35054586"xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.org/dc/terms/identifier | "doi:10.1038/35054586"xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Coll M."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Coll M."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Gonzalez A."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Gonzalez A."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Gomis-Ruth F.X."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Gomis-Ruth F.X."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Moncalian G."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Moncalian G."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Cabezon E."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Cabezon E."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Perez-Luque R."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "Perez-Luque R."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "de la Cruz F."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/author | "de la Cruz F."xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/pages | "637-641"xsd:string |
| http://purl.uniprot.org/citations/11214325 | http://purl.uniprot.org/core/pages | "637-641"xsd:string |