| http://purl.uniprot.org/citations/11224563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11224563 | http://www.w3.org/2000/01/rdf-schema#comment | "Bovine pancreatic ribonuclease (RNase A) forms two types of dimers (a major and a minor component) upon concentration in mild acid. These two dimers exhibit different biophysical and biochemical properties. Earlier we reported that the minor dimer forms by swapping its N-terminal alpha-helix with that of an identical molecule. Here we find that the major dimer forms by swapping its C-terminal beta-strand, thus revealing the first example of three-dimensional (3D) domain swapping taking place in different parts of the same protein. This feature permits RNase A to form tightly bonded higher oligomers. The hinge loop of the major dimer, connecting the swapped beta-strand to the protein core, resembles a short segment of the polar zipper proposed by Perutz and suggests a model for aggregate formation by 3D domain swapping with a polar zipper."xsd:string |
| http://purl.uniprot.org/citations/11224563 | http://purl.org/dc/terms/identifier | "doi:10.1038/84941"xsd:string |
| http://purl.uniprot.org/citations/11224563 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/11224563 | http://purl.uniprot.org/core/author | "Eisenberg D."xsd:string |
| http://purl.uniprot.org/citations/11224563 | http://purl.uniprot.org/core/author | "Gotte G."xsd:string |
| http://purl.uniprot.org/citations/11224563 | http://purl.uniprot.org/core/author | "Libonati M."xsd:string |
| http://purl.uniprot.org/citations/11224563 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11224563 | http://purl.uniprot.org/core/name | "Nat Struct Biol"xsd:string |
| http://purl.uniprot.org/citations/11224563 | http://purl.uniprot.org/core/pages | "211-214"xsd:string |
| http://purl.uniprot.org/citations/11224563 | http://purl.uniprot.org/core/title | "A domain-swapped RNase A dimer with implications for amyloid formation."xsd:string |
| http://purl.uniprot.org/citations/11224563 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11224563 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11224563 |
| http://purl.uniprot.org/citations/11224563 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11224563 |
| http://purl.uniprot.org/uniprot/#_P61823-mappedCitation-11224563 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11224563 |
| http://purl.uniprot.org/uniprot/P61823 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11224563 |