| http://purl.uniprot.org/citations/11226248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11226248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11226248 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we show that presenilin-1 (PS1), a protein involved in Alzheimer's disease, binds directly to epithelial cadherin (E-cadherin). This binding is mediated by the large cytoplasmic loop of PS1 and requires the membrane-proximal cytoplasmic sequence 604-615 of mature E-cadherin. This sequence is also required for E-cadherin binding of protein p120, a known regulator of cadherin-mediated cell adhesion. Using wild-type and PS1 knockout cells, we found that increasing PS1 levels suppresses p120/E-cadherin binding, and increasing p120 levels suppresses PS1/E-cadherin binding. Thus PS1 and p120 bind to and mutually compete for cellular E-cadherin. Furthermore, PS1 stimulates E-cadherin binding to beta- and gamma-catenin, promotes cytoskeletal association of the cadherin/catenin complexes, and increases Ca(2+)-dependent cell-cell aggregation. Remarkably, PS1 familial Alzheimer disease mutant DeltaE9 increased neither the levels of cadherin/catenin complexes nor cell aggregation, suggesting that this familial Alzheimer disease mutation interferes with cadherin-based cell-cell adhesion. These data identify PS1 as an E-cadherin-binding protein and a regulator of E-cadherin function in vivo."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.041603398"xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.041603398"xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Efthimiopoulos S."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Efthimiopoulos S."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Robakis N.K."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Robakis N.K."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Shioi J."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Shioi J."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Ozawa M."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Ozawa M."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Cui W."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Cui W."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Baki L."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Baki L."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Friedrich V.L."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Friedrich V.L."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Georgakopoulos A."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Georgakopoulos A."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Koo E."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Koo E."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Marambaud P."xsd:string |
| http://purl.uniprot.org/citations/11226248 | http://purl.uniprot.org/core/author | "Marambaud P."xsd:string |