| http://purl.uniprot.org/citations/11226327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11226327 | http://www.w3.org/2000/01/rdf-schema#comment | "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages dopaminergic neurons in the substantia nigra pars compacta (SNpc) as seen in Parkinson's disease. Here, we show that the pro-apoptotic protein Bax is highly expressed in the SNpc and that its ablation attenuates SNpc developmental neuronal apoptosis. In adult mice, there is an up-regulation of Bax in the SNpc after MPTP administration and a decrease in Bcl-2. These changes parallel MPTP-induced dopaminergic neurodegeneration. We also show that mutant mice lacking Bax are significantly more resistant to MPTP than their wild-type littermates. This study demonstrates that Bax plays a critical role in the MPTP neurotoxic process and suggests that targeting Bax may provide protective benefit in the treatment of Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.051633998"xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/author | "Korsmeyer S.J."xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/author | "Jackson-Lewis V."xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/author | "Djaldetti R."xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/author | "Przedborski S."xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/author | "Vila M."xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/author | "Liberatore G."xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/author | "Offen D."xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/author | "Vukosavic S."xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/pages | "2837-2842"xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/title | "Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/11226327 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11226327 |
| http://purl.uniprot.org/citations/11226327 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11226327 |
| http://purl.uniprot.org/uniprot/#_A0A165ELP6-mappedCitation-11226327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11226327 |
| http://purl.uniprot.org/uniprot/#_P10417-mappedCitation-11226327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11226327 |
| http://purl.uniprot.org/uniprot/#_Q07813-mappedCitation-11226327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11226327 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT35-mappedCitation-11226327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11226327 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT81-mappedCitation-11226327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11226327 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GTA4-mappedCitation-11226327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11226327 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS13-mappedCitation-11226327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11226327 |