| http://purl.uniprot.org/citations/11229461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11229461 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo further characterize the HLA gene products that play an important role in the pathogenesis of rheumatoid arthritis (RA).MethodsOne hundred thirty-four haplotypes from 67 Finnish RA patients and 77 control haplotypes were analyzed for HLA-DRB1 loci, associated alleles of the HLA-DQB1 locus, alleles of the type 2 transporter-associated antigen processing (TAP2) genes, and HLA-B27. In addition, a panel of microsatellite markers within the HLA class I and class III regions was studied.ResultsThe frequency of HLA-DRB1*04 in the haplotypes of RA patients was found to be 34% (45 of 134) compared with 14% (10 of 72) in control haplotypes (P = 0.004). The frequency of HLA-DRB1*13 was decreased in RA haplotypes (4%, or 5 of 134) in contrast to control haplotypes (24%, or 17 of 72) (P = 0.000031). The decrease in DRB1*13 was not secondary to the increase in DRB1*04, since it was also found among DRB1*04-negative haplotypes (P < 0.001). The DRB1*13-associated DQB1*0604 allele was similarly decreased in RA haplotypes (P = 0.025). The TAP2I allele of I/J dimorphism was increased in RA patients (85%, or 114 of 134) as compared with controls (69%, or 49 of 71) (P = 0.011). Of the tumor necrosis factor (TNF) microsatellite alleles, TNFa6 and TNFb5 were found to be increased in RA haplotypes (for a6 27% versus 5% in controls [P = 0.00043], and for b5 43% versus 26% in controls [P = 0.037]).ConclusionBoth protection-associated and susceptibility-associated alleles can be found among HLA class II genes, and the results suggest that loci outside DR/DQ may contribute to the pathogenesis of RA."xsd:string |
| http://purl.uniprot.org/citations/11229461 | http://purl.org/dc/terms/identifier | "doi:10.1002/1529-0131(200102)44:2<315::aid-anr48>3.0.co;2-g"xsd:string |
| http://purl.uniprot.org/citations/11229461 | http://purl.uniprot.org/core/author | "Nejentsev S."xsd:string |
| http://purl.uniprot.org/citations/11229461 | http://purl.uniprot.org/core/author | "Ilonen J."xsd:string |
| http://purl.uniprot.org/citations/11229461 | http://purl.uniprot.org/core/author | "Luukkainen R."xsd:string |
| http://purl.uniprot.org/citations/11229461 | http://purl.uniprot.org/core/author | "Toivanen A."xsd:string |
| http://purl.uniprot.org/citations/11229461 | http://purl.uniprot.org/core/author | "Tuokko J."xsd:string |
| http://purl.uniprot.org/citations/11229461 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11229461 | http://purl.uniprot.org/core/name | "Arthritis Rheum"xsd:string |
| http://purl.uniprot.org/citations/11229461 | http://purl.uniprot.org/core/pages | "315-322"xsd:string |
| http://purl.uniprot.org/citations/11229461 | http://purl.uniprot.org/core/title | "HLA haplotype analysis in Finnish patients with rheumatoid arthritis."xsd:string |
| http://purl.uniprot.org/citations/11229461 | http://purl.uniprot.org/core/volume | "44"xsd:string |
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