| http://purl.uniprot.org/citations/11238463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11238463 | http://www.w3.org/2000/01/rdf-schema#comment | "Growth factor-induced signaling by receptor tyrosine kinases (RTKs) plays a central role in embryonic development and in pathogenesis and, hence, is tightly controlled by several regulatory proteins. Recently, Sprouty, an inhibitor of Drosophila development-associated RTK signaling, has been discovered. Subsequently, four mammalian Sprouty homologues (Spry-1-4) have been identified. Here, we report the functional characterization of two of them, Spry-1 and -2, in endothelial cells. Overexpressed Spry-1 and -2 inhibit fibroblast growth factor- and vascular endothelial growth factor-induced proliferation and differentiation by repressing pathways leading to p42/44 mitogen-activating protein (MAP) kinase activation. In contrast, although epidermal growth factor-induced proliferation of endothelial cells was also inhibited by Spry-1 and -2, activation of p42/44 MAP kinase was not affected. Biochemical and immunofluorescence analysis of endogenous and overexpressed Spry-1 and -2 reveal that both Spry-1 and -2 are anchored to membranes by palmitoylation and associate with caveolin-1 in perinuclear and vesicular structures. They are phosphorylated on serine residues and, upon growth factor stimulation, a subset is recruited to the leading edge of the plasma membrane. The data indicate that mammalian Spry-1 and -2 are membrane-anchored proteins that negatively regulate angiogenesis-associated RTK signaling, possibly in a RTK-specific fashion."xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.152.5.1087"xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/author | "Cotten M."xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/author | "Weitzer S."xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/author | "Christofori G."xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/author | "Compagni A."xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/author | "Gannon G."xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/author | "Impagnatiello M.A."xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/pages | "1087-1098"xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/title | "Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://purl.uniprot.org/core/volume | "152"xsd:string |
| http://purl.uniprot.org/citations/11238463 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11238463 |
| http://purl.uniprot.org/citations/11238463 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11238463 |
| http://purl.uniprot.org/uniprot/#_B2RS85-mappedCitation-11238463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11238463 |
| http://purl.uniprot.org/uniprot/#_P62714-mappedCitation-11238463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11238463 |
| http://purl.uniprot.org/uniprot/#_Q53ZU1-mappedCitation-11238463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11238463 |
| http://purl.uniprot.org/uniprot/#_O43597-mappedCitation-11238463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11238463 |
| http://purl.uniprot.org/uniprot/#_P30153-mappedCitation-11238463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11238463 |
| http://purl.uniprot.org/uniprot/#_P67775-mappedCitation-11238463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11238463 |
| http://purl.uniprot.org/uniprot/#_Q3UUD2-mappedCitation-11238463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11238463 |
| http://purl.uniprot.org/uniprot/#_Q8CET5-mappedCitation-11238463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11238463 |
| http://purl.uniprot.org/uniprot/#_Q8CHU2-mappedCitation-11238463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11238463 |