| http://purl.uniprot.org/citations/11238636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11238636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11238636 | http://www.w3.org/2000/01/rdf-schema#comment | "Family studies of first-degree relatives and analysis of twins indicate that as much as 75% of the differences in quantitative IL-10 production in man derive from heritable genetic factors. Studies of single nucleotide polymorphisms (SNP) in the proximal 1.0 kb of the IL-10 promoter have yielded inconsistent association with IL-10 production and variable results in promoter-reporter studies. However, in normal donors, an association of quantitative production with certain alleles of the IL-10.R short tandem repeat polymorphism at -4.0 kb suggested that SNPs in the more distal promoter might be informative. We have identified seven novel SNP sites in the genomic sequence of the first 4 kb of the IL-10 promoter region 5' to the ATG start site from Caucasian individuals with either a high or a low IL-10 production phenotype. We have also identified eight SNP haplotypes in the distal promoter that segregate with significant differences in quantitative IL-10 production in normal donors. These SNPs are significantly associated with systemic lupus erythematosus in African-Americans and may define one component of the genetic susceptibility to systemic lupus erythematosus in this group."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.166.6.3915"xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Kimberly R.P."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Kimberly R.P."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Edberg J.C."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Edberg J.C."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Gibson A.W."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Gibson A.W."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Huizinga T.W."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Huizinga T.W."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Westendorp R.G."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/author | "Westendorp R.G."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/pages | "3915-3922"xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/pages | "3915-3922"xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/title | "Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/title | "Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus."xsd:string |
| http://purl.uniprot.org/citations/11238636 | http://purl.uniprot.org/core/volume | "166"xsd:string |