| http://purl.uniprot.org/citations/11238996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11238996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11238996 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously isolated the hpttg proto-oncogene, which is expressed in normal tissues containing proliferating cells and in several kinds of tumors. In fact, expression of hPTTG correlates with cell proliferation in a cell cycle-dependent manner. Recently it was reported that PTTG is a vertebrate analog of the yeast securins Pds1 and Cut2, which are involved in sister chromatid separation. Here we show that hPTTG binds to Ku, the regulatory subunit of the DNA-dependent protein kinase (DNA-PK). hPTTG and Ku associate both in vitro and in vivo and the DNA-PK catalytic subunit phosphorylates hPTTG in vitro. Furthermore, DNA double-strand breaks prevent hPTTG-Ku association and disrupt the hPTTG-Ku complexes, indicating that genome damaging events, which result in the induction of pathways that activate DNA repair mechanisms and halt cell cycle progression, might inhibit hPTTG-Ku interaction in vivo. We propose that hPTTG might connect DNA damage-response pathways with sister chromatid separation, delaying the onset of mitosis while DNA repair occurs."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/29.6.1300"xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/29.6.1300"xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Dominguez A."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Dominguez A."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Pintor-Toro J.A."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Pintor-Toro J.A."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Romero F."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Romero F."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Ramos-Morales F."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Ramos-Morales F."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Bernal J.A."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Bernal J.A."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Multon M.C."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Multon M.C."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Tortolero M."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/author | "Tortolero M."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/pages | "1300-1307"xsd:string |
| http://purl.uniprot.org/citations/11238996 | http://purl.uniprot.org/core/pages | "1300-1307"xsd:string |