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http://purl.uniprot.org/citations/11239517http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11239517http://www.w3.org/2000/01/rdf-schema#comment"

Background

The HLA-DQB1 chain, in particular the amino acid in position 57, and genetic variants of the vitamin D-binding protein (DBP) have been reported to be associated with type 1 diabetes. There are two known polymorphisms in exon 11 of the DBP gene resulting in amino acid variants: codons 416 GAT --> GAG (Asp --> Glu) and 420 ACG --> AAG (Thr --> Lys). We compared distribution of DQB1 alleles and amino acid variants of DBP in type 1 diabetic patients (n = 44) in the Alsacian population and in healthy controls (n = 58).

Methods

The second exon of the DQB1 gene and exon 11 of DBP were analyzed by restriction mapping after polymerase chain reaction.

Results

A significant enrichment in DQB1 alleles encoding for an amino acid different from Asp in position 57 (NA) was observed in diabetic subjects as compared to controls (94.3 vs. 32.8%; p < 0.001). Combinations other than Ala/Ala carried the highest relative risk (OR = 52; p < 0.001). The analysis of the polymorphism in exon 11 of DBP showed a significant difference in the allele frequency of the HaeIII site, but not of the StyI site between patients and controls. Allele frequencies of HaeIII in diabetic subjects were 36% and 64% for Asp and Glu respectively (p < 0.001; chi(2) = 29.5). The frequency of Asp/Asp and Glu/Glu genotypes was increased in controls and diabetic subjects respectively. DBP alleles in individuals carrying the DQB1 NA combination revealed that 46.6% of diabetics were DBP Asp/Glu, but this was not statistically significant using the Fisher exact test (16/31 vs. 0/3; p = 0.23).

Conclusions

The study of the DQB1 chain confirmed the value of alleles encoding for an amino acid different from Asp in position 57 (NA) in the susceptibility to type 1 diabetes. The allele frequency of the HaeIII site, but not of the StyI site, differed between patients and controls (HaeIII p < 0.001; StyI p > 0.05)."xsd:string
http://purl.uniprot.org/citations/11239517http://purl.org/dc/terms/identifier"doi:10.1016/s0009-9120(00)00197-1"xsd:string
http://purl.uniprot.org/citations/11239517http://purl.uniprot.org/core/author"Belcourt A."xsd:string
http://purl.uniprot.org/citations/11239517http://purl.uniprot.org/core/author"Kaltenbacher M.C."xsd:string
http://purl.uniprot.org/citations/11239517http://purl.uniprot.org/core/author"Ongagna J.C."xsd:string
http://purl.uniprot.org/citations/11239517http://purl.uniprot.org/core/author"Pinget M."xsd:string
http://purl.uniprot.org/citations/11239517http://purl.uniprot.org/core/author"Sapin R."xsd:string
http://purl.uniprot.org/citations/11239517http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11239517http://purl.uniprot.org/core/name"Clin Biochem"xsd:string
http://purl.uniprot.org/citations/11239517http://purl.uniprot.org/core/pages"59-63"xsd:string
http://purl.uniprot.org/citations/11239517http://purl.uniprot.org/core/title"The HLA-DQB alleles and amino acid variants of the vitamin D-binding protein in diabetic patients in Alsace."xsd:string
http://purl.uniprot.org/citations/11239517http://purl.uniprot.org/core/volume"34"xsd:string
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