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http://purl.uniprot.org/citations/11240025http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11240025http://www.w3.org/2000/01/rdf-schema#comment"Class A scavenger receptors (SR-A) mediate microglial interaction with fibrillar beta-amyloid (fAbeta). We report here that neonatal microglia from SR-A knockout mice (SR-A-/-) adhere to surface-bound fAbeta, and produce reactive oxygen species (ROS) as efficiently as wildtype microglia; that both wildtype and SR-A-/-microglia express SR-BI; that antibodies against SR-BI do not affect adhesion or ROS production by wildtype microglia, but inhibit adhesion and ROS production of SR-A-/-microglia to immobilized fAbeta by approximately 40%. Adhesion to fAbeta-coated surfaces, and uptake of fAbeta by both wildtype and SR-A-/-microglia was almost completely inhibited by incubation with fucoidan. Thus SR-BI and SR-A mediate similar effector functions in neonatal microglia, which suggests that SR-BI plays as important a role as SR-A, and can maintain the wildtype phenotype in SR-A-/- microglia."xsd:string
http://purl.uniprot.org/citations/11240025http://purl.org/dc/terms/identifier"doi:10.1016/s0165-5728(01)00239-9"xsd:string
http://purl.uniprot.org/citations/11240025http://purl.uniprot.org/core/author"Kodama T."xsd:string
http://purl.uniprot.org/citations/11240025http://purl.uniprot.org/core/author"Silverstein S.C."xsd:string
http://purl.uniprot.org/citations/11240025http://purl.uniprot.org/core/author"Loike J.D."xsd:string
http://purl.uniprot.org/citations/11240025http://purl.uniprot.org/core/author"Husemann J."xsd:string
http://purl.uniprot.org/citations/11240025http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11240025http://purl.uniprot.org/core/name"J Neuroimmunol"xsd:string
http://purl.uniprot.org/citations/11240025http://purl.uniprot.org/core/pages"142-150"xsd:string
http://purl.uniprot.org/citations/11240025http://purl.uniprot.org/core/title"Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid."xsd:string
http://purl.uniprot.org/citations/11240025http://purl.uniprot.org/core/volume"114"xsd:string
http://purl.uniprot.org/citations/11240025http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11240025
http://purl.uniprot.org/citations/11240025http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11240025
http://purl.uniprot.org/uniprot/Q07954#attribution-E953B5432B782EEFC2FAA3060D71A0C0http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/11240025
http://purl.uniprot.org/uniprot/P30204#attribution-A792392FC8AF41EBEA6045534BB1D403http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/11240025
http://purl.uniprot.org/uniprot/P30204#attribution-BF890F46C232745DFD9D827643B7170Bhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/11240025
http://purl.uniprot.org/uniprot/P21757#attribution-E953B5432B782EEFC2FAA3060D71A0C0http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/11240025
http://purl.uniprot.org/uniprot/Q15109#attribution-E953B5432B782EEFC2FAA3060D71A0C0http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/11240025
http://purl.uniprot.org/uniprot/Q61009#attribution-BF890F46C232745DFD9D827643B7170Bhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/11240025
http://purl.uniprot.org/uniprot/#_D3Z5U8-mappedCitation-11240025http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11240025
http://purl.uniprot.org/uniprot/#_A0A1B0GRS5-mappedCitation-11240025http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11240025
http://purl.uniprot.org/uniprot/#_F7C5U2-mappedCitation-11240025http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11240025
http://purl.uniprot.org/uniprot/#_Q3U2C3-mappedCitation-11240025http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11240025
http://purl.uniprot.org/uniprot/#_Q8BNQ0-mappedCitation-11240025http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11240025