| http://purl.uniprot.org/citations/11242035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11242035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11242035 | http://www.w3.org/2000/01/rdf-schema#comment | "In all synapses, Ca2+ triggers neurotransmitter release to initiate signal transmission. Ca2+ presumably acts by activating synaptic Ca2+ sensors, but the nature of these sensors--which are the gatekeepers to neurotransmission--remains unclear. One of the candidate Ca2+ sensors in release is the synaptic Ca2+-binding protein synaptotagmin I. Here we have studied a point mutation in synaptotagmin I that causes a twofold decrease in overall Ca2+ affinity without inducing structural or conformational changes. When introduced by homologous recombination into the endogenous synaptotagmin I gene in mice, this point mutation decreases the Ca2+ sensitivity of neurotransmitter release twofold, but does not alter spontaneous release or the size of the readily releasable pool of neurotransmitters. Therefore, Ca2+ binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.org/dc/terms/identifier | "doi:10.1038/35065004"xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.org/dc/terms/identifier | "doi:10.1038/35065004"xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Garcia J."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Garcia J."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Matos M.F."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Matos M.F."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Rizo J."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Rizo J."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Brose N."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Brose N."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Rosenmund C."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Rosenmund C."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Koenigstorfer A."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Koenigstorfer A."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Fernandez-Chacon R."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Fernandez-Chacon R."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Stevens C.F."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Stevens C.F."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Gerber S.H."xsd:string |
| http://purl.uniprot.org/citations/11242035 | http://purl.uniprot.org/core/author | "Gerber S.H."xsd:string |