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http://purl.uniprot.org/citations/11242108http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11242108http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11242108http://www.w3.org/2000/01/rdf-schema#comment"In Saccharomyces cerevisiae, meiotic recombination is initiated by Spo11-dependent double-strand breaks (DSBs), a process that precedes homologous synapsis. Here we use an antibody specific for a phosphorylated histone (gamma-H2AX, which marks the sites of DSBs) to investigate the timing, distribution and Spo11-dependence of meiotic DSBs in the mouse. We show that, as in yeast, recombination in the mouse is initiated by Spo11-dependent DSBs that form during leptotene. Loss of gamma-H2AX staining (which in irradiated somatic cells is temporally linked with DSB repair) is temporally and spatially correlated with synapsis, even when this synapsis is 'non-homologous'."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.org/dc/terms/identifier"doi:10.1038/85830"xsd:string
http://purl.uniprot.org/citations/11242108http://purl.org/dc/terms/identifier"doi:10.1038/85830"xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Bonner W.M."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Bonner W.M."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Rogakou E.P."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Rogakou E.P."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Keeney S."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Keeney S."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Jasin M."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Jasin M."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"de Boer P."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"de Boer P."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Turner J.M.A."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Turner J.M.A."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Burgoyne P.S."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Burgoyne P.S."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Baudat F."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Baudat F."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Blanco-Rodriguez J."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Blanco-Rodriguez J."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Mahadevaiah S.K."xsd:string
http://purl.uniprot.org/citations/11242108http://purl.uniprot.org/core/author"Mahadevaiah S.K."xsd:string