| http://purl.uniprot.org/citations/11245572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11245572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11245572 | http://www.w3.org/2000/01/rdf-schema#comment | "In remarkable contrast to somatic cells, the germline of the nematode Caenorhabditis elegans efficiently silences transgenic DNA. The molecular mechanisms responsible for this have been shown to implicate chromatin proteins encoded by the mes genes (Kelly, W. G. and Fire, A. (1998) Development 125, 2451-2456), of which two are the C. elegans homologs of Polycomb Group gene transcriptional repressors. We have analyzed the contribution of the histone H1 gene family to this specific aspect of germ cells in C. elegans. We show with isotype-specific double stranded RNA-mediated interference (RNAi) that a single member of this gene family (H1.1) is essential for the repression of a silenced reporter-transgene in the germline of hermaphrodites and males, whereas no change is found in the somatic expression of this reporter. Additionally, RNA-mediated interference with H1.1 gene expression can cause a phenotype with severe affection of germline proliferation and differentiation in the hermaphrodite, and even sterility (5%-11% penetrance). These and further features observed in histone H1.1 RNAi experiments are also characteristic of the mes phenotype (Garvin, C., Holdeman, R. and Strome, S. (1998) Genetics 148, 167-185), which is believed to result from the desilencing of genes required for somatic differentiation in the germline. Our observations therefore support this interpretation of the mes phenotype and they identify a single histone H1 isoform (H1.1) as a new component specifically involved in chromatin silencing in the germline of C. elegans."xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.128.7.1069"xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.128.7.1069"xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/author | "Schulze E."xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/author | "Schulze E."xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/author | "Jedrusik M.A."xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/author | "Jedrusik M.A."xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/pages | "1069-1080"xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/pages | "1069-1080"xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/title | "A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/title | "A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/11245572 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11245572 |
| http://purl.uniprot.org/citations/11245572 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11245572 |
| http://purl.uniprot.org/citations/11245572 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11245572 |
| http://purl.uniprot.org/citations/11245572 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11245572 |
| http://purl.uniprot.org/embl-cds/AAB82588.1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11245572 |
| http://purl.uniprot.org/uniprot/Q19743 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11245572 |