| http://purl.uniprot.org/citations/11246230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11246230 | http://www.w3.org/2000/01/rdf-schema#comment | "Individuals with neurofibromatosis 1 (NF1) develop low-grade astrocytomas at an increased frequency. To gain insight into the function of the Nf1 gene product as a growth regulator for astrocytes, we examined mice heterozygous for a targeted Nf1 mutation. In our previous studies, we demonstrated increased numbers of proliferating astrocytes in Nf1 heterozygote (Nf1+/-) mice in vivo. We now show that cultured Nf1+/-astrocytes exhibit a cell-autonomous growth advantage in vitro associated with increased p21-ras pathway activation. Furthermore, we demonstrate that Nf1+/-;wild-type N-ras mice have a similar astrocyte growth advantage in vitro and in vivo as either oncogenic N-ras or Nf1+/-; oncogenic N-ras mice. Lastly, mice heterozygous for targeted defects in both Nf1 and p53 as well as Nf1 and Rb exhibit 3- and 2.5-fold increases in astrocyte proliferation in vivo, respectively, suggesting that abnormalities in Nf1- and p53/Rb-regulated pathways cooperate in the heterozygous state to confer a growth advantage for brain astrocytes. Collectively, these results provide evidence for a cell-autonomous growth advantage in Nf1+/-astrocytes and suggest that some of the brain pathology in individuals with NF1 might result from reduced, but not absent, NF1 gene function."xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.org/dc/terms/identifier | "doi:10.1002/1098-1136(20010315)33:4<314::aid-glia1030>3.0.co;2-q"xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/author | "Gutmann D.H."xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/author | "Pellicer A."xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/author | "Brophy S."xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/author | "Corral T."xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/author | "Reilly K.M."xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/author | "Bajenaru M.L."xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/author | "Donahoe J."xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/name | "Glia"xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/pages | "314-323"xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/title | "Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes."xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/11246230 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11246230 |
| http://purl.uniprot.org/citations/11246230 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11246230 |
| http://purl.uniprot.org/uniprot/Q04690#attribution-F2B52FD9EDD50E4C45B339745DBD8DAB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11246230 |
| http://purl.uniprot.org/uniprot/P02340#attribution-8AFD67776E017B6E0A71EBF4B4454AB4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11246230 |
| http://purl.uniprot.org/uniprot/P13405#attribution-8AFD67776E017B6E0A71EBF4B4454AB4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11246230 |
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| http://purl.uniprot.org/uniprot/#_A0A286YDU0-mappedCitation-11246230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11246230 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-11246230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11246230 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P863-mappedCitation-11246230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11246230 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-11246230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11246230 |