| http://purl.uniprot.org/citations/11250900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11250900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11250900 | http://www.w3.org/2000/01/rdf-schema#comment | "One class of the nuclear receptor AF-2 coactivator complexes contains the SRC-1/TIF2 family, CBP/p300 and an RNA coactivator, SRA. We identified a subfamily of RNA-binding DEAD-box proteins (p72/p68) as a human estrogen receptor alpha (hER alpha) coactivator in the complex containing these factors. p72/p68 interacted with both the AD2 of any SRC-1/TIF2 family protein and the hER alpha A/B domain, but not with any other nuclear receptor tested. p72/p68, TIF2 (SRC-1) and SRA were co-immunoprecipitated with estrogen-bound hER alpha in MCF7 cells and in partially purified complexes associated with hER alpha from HeLa nuclear extracts. Estrogen induced co-localization of p72 with hER alpha and TIF2 in the nucleus. The presence of p72/p68 potentiated the estrogen-induced expression of the endogenous pS2 gene in MCF7 cells. In a transient expression assay, a combination of p72/p68 with SRA and one TIF2 brought an ultimate synergism to the estrogen-induced transactivation of hER alpha. These findings indicate that p72/p68 acts as an ER subtype-selective coactivator through ER alpha AF-1 by associating with the coactivator complex to bind its AF-2 through direct binding with SRA and the SRC-1/TIF2 family proteins."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.6.1341"xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.6.1341"xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Kitagawa H."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Kitagawa H."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Kato S."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Kato S."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Yoshikawa H."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Yoshikawa H."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Yano T."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Yano T."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Takeyama K."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Takeyama K."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Suzawa M."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Suzawa M."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Yanagisawa J."xsd:string |
| http://purl.uniprot.org/citations/11250900 | http://purl.uniprot.org/core/author | "Yanagisawa J."xsd:string |