| http://purl.uniprot.org/citations/11250903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11250903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11250903 | http://www.w3.org/2000/01/rdf-schema#comment | "A crucial step in transcription is the recruitment of RNA polymerase to promoters. In the transcription of human rRNA genes by RNA Polymerase I (Pol I), transcription factor SL1 has a role as the essential core promoter binding factor. Little is known about the mechanism by which Pol I is recruited. We provide evidence for an essential role for hRRN3, the human homologue of a yeast Pol I transcription factor, in this process. We find that whereas the bulk of human Pol I complexes (I alpha) are transcriptionally inactive, hRRN3 defines a distinct subpopulation of Pol I complexes (I beta) that supports specific initiation of transcription. Human RRN3 interacts directly with TAF(I)110 and TAF(I)63 of promoter-selectivity factor SL1. Blocking this connection prevents recruitment of Pol I beta to the rDNA promoter. Furthermore, hRRN3 can be found in transcriptionally autonomous Pol I holoenzyme complexes. We conclude that hRRN3 functions to recruit initiation-competent Pol I to rRNA gene promoters. The essential role for hRRN3 in linking Pol I to SL1 suggests a mechanism for growth control of Pol I transcription."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.6.1373"xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.6.1373"xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Miller G."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Miller G."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Lamond A.I."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Lamond A.I."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Trinkle-Mulcahy L."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Trinkle-Mulcahy L."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Panov K.I."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Panov K.I."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Zomerdijk J.C.B.M."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Zomerdijk J.C.B.M."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Friedrich J.K."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/author | "Friedrich J.K."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/pages | "1373-1382"xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/pages | "1373-1382"xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/title | "hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters."xsd:string |
| http://purl.uniprot.org/citations/11250903 | http://purl.uniprot.org/core/title | "hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters."xsd:string |