| http://purl.uniprot.org/citations/11251067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11251067 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphatidylcholine and phosphatidylethanolamine are the most abundant phospholipids in eukaryotic cells and thus have major roles in the formation and maintenance of vesicular membranes. In yeast, diacylglycerol accepts a phosphocholine moiety through a CPT1-derived cholinephosphotransferase activity to directly synthesize phosphatidylcholine. EPT1-derived activity can transfer either phosphocholine or phosphoethanolamine to diacylglcyerol in vitro, but is currently believed to primarily synthesize phosphatidylethanolamine in vivo. In this study we report that CPT1- and EPT1-derived cholinephosphotransferase activities can significantly overlap in vivo such that EPT1 can contribute to 60% of net phosphatidylcholine synthesis via the Kennedy pathway. Alterations in the level of diacylglycerol consumption through alterations in phosphatidylcholine synthesis directly correlated with the level of SEC14-dependent invertase secretion and affected cell viability. Administration of synthetic di8:0 diacylglycerol resulted in a partial rescue of cells from SEC14-mediated cell death. The addition of di8:0 diacylglycerol increased di8:0 diacylglycerol levels 20-40-fold over endogenous long-chain diacylglycerol levels. Di8:0 diacylglcyerol did not alter endogenous phospholipid metabolic pathways, nor was it converted to di8:0 phosphatidic acid."xsd:string |
| http://purl.uniprot.org/citations/11251067 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.12.3.511"xsd:string |
| http://purl.uniprot.org/citations/11251067 | http://purl.uniprot.org/core/author | "McMaster C.R."xsd:string |
| http://purl.uniprot.org/citations/11251067 | http://purl.uniprot.org/core/author | "Henneberry A.L."xsd:string |
| http://purl.uniprot.org/citations/11251067 | http://purl.uniprot.org/core/author | "Ridgway N.D."xsd:string |
| http://purl.uniprot.org/citations/11251067 | http://purl.uniprot.org/core/author | "Lagace T.A."xsd:string |
| http://purl.uniprot.org/citations/11251067 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11251067 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/11251067 | http://purl.uniprot.org/core/pages | "511-520"xsd:string |
| http://purl.uniprot.org/citations/11251067 | http://purl.uniprot.org/core/title | "Phosphatidylcholine synthesis influences the diacylglycerol homeostasis required for SEC14p-dependent Golgi function and cell growth."xsd:string |
| http://purl.uniprot.org/citations/11251067 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/11251067 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11251067 |
| http://purl.uniprot.org/citations/11251067 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11251067 |
| http://purl.uniprot.org/uniprot/#_P22140-mappedCitation-11251067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11251067 |
| http://purl.uniprot.org/uniprot/#_P17898-mappedCitation-11251067 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11251067 |
| http://purl.uniprot.org/uniprot/P22140 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11251067 |
| http://purl.uniprot.org/uniprot/P17898 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11251067 |