| http://purl.uniprot.org/citations/11251120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11251120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11251120 | http://www.w3.org/2000/01/rdf-schema#comment | "The activation of gp130, a shared signal-transducing receptor for a family of cytokines, is initiated by recognition of ligand followed by oligomerization into a higher order signaling complex. Kaposi's sarcoma-associated herpesvirus encodes a functional homolog of human interleukin-6 (IL-6) that activates human gp130. In the 2.4 angstrom crystal structure of the extracellular signaling assembly between viral IL-6 and human gp130, two complexes are cross-linked into a tetramer through direct interactions between the immunoglobulin domain of gp130 and site III of viral IL-6, which is necessary for receptor activation. Unlike human IL-6 (which uses many hydrophilic residues), the viral cytokine largely uses hydrophobic amino acids to contact gp130, which enhances the complementarity of the viral IL-6-gp130 binding interfaces. The cross-reactivity of gp130 is apparently due to a chemical plasticity evident in the amphipathic gp130 cytokine-binding sites."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1058308"xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1058308"xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "Rose-John S."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "Rose-John S."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "He X.-L."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "He X.-L."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "Chow D.-C."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "Chow D.-C."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "Chow D."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "Snow A.L."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/author | "Snow A.L."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/pages | "2150-2155"xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/pages | "2150-2155"xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/title | "Structure of an extracellular gp130 cytokine receptor signaling complex."xsd:string |
| http://purl.uniprot.org/citations/11251120 | http://purl.uniprot.org/core/title | "Structure of an extracellular gp130 cytokine receptor signaling complex."xsd:string |