| http://purl.uniprot.org/citations/11251963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11251963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11251963 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated a novel human lung-specific gene, LUNX (lung-specific X protein), by differential-display mRNA analysis. The full-length cDNA contained 1,015 nucleotides including an open reading frame of 768 nucleotides encoding 256 amino acids. We localized the gene to chromosomal region 20p11.1-q12 by radiation hybrid mapping. Using an RT-PCR assay specific for LUNX mRNA, 35 non-small-cell lung-cancer (NSCLC) tumors and 0 of 16 normal lymph nodes were positive. Furthermore, LUNX mRNA expression was enhanced in 26 (84%) of 31 NSCLC tumors vs. corresponding cancer-free lung tissues by semi-quantitative analyses with multiplex RT-PCR. We assessed the possibility of LUNX mRNA as a molecular marker for detection of micrometastasis in dissected lymph nodes obtained from 20 patients with NSCLC tumors. LUNX mRNA was detected in 16 (80%) of 20 histologically positive lymph nodes and 21 (25%) of 84 histologically negative lymph nodes. Comparative analyses of the conventional histological examination and the RT-PCR detection assay for LUNX mRNA showed that the detection rate of metastases in lymph nodes by the RT-PCR assay was higher in 12 and consistent in 6 of the total 20 NSCLC patients. We demonstrate that the LUNX RT-PCR assay is a potential diagnostic method for detection of micrometastases in lymph nodes of NSCLC patients."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.org/dc/terms/identifier | "doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1059>3.0.co;2-b"xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.org/dc/terms/identifier | "doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1059>3.0.co;2-b"xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Fujiwara Y."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Fujiwara Y."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Ozaki K."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Ozaki K."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Tanigami A."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Tanigami A."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Kodama K."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Kodama K."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Higashiyama M."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Higashiyama M."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Yokouchi H."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Yokouchi H."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Monden M."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Monden M."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Iwao K."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Iwao K."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Takami K."xsd:string |
| http://purl.uniprot.org/citations/11251963 | http://purl.uniprot.org/core/author | "Takami K."xsd:string |