| http://purl.uniprot.org/citations/11252174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11252174 | http://www.w3.org/2000/01/rdf-schema#comment | "Familial combined hyperlipidemia (FCHL) is a common genetic dyslipidemia predisposing to premature coronary heart disease (CHD). We previously identified a locus for FCHL on human Chromosome (Chr) 1q21-q23 in 31 Finnish FCHL families. We also mapped a gene for combined hyperlipidemia (Hyplip1) to a potentially orthologous region of mouse Chr 3 in the HcB-19/Dem mouse model of FCHL. The human FCHL locus was, however, originally mapped about 5 Mb telomeric to the synteny border, the centromeric part of which is homologous to mouse Chr 3 and the telomeric part to mouse Chr 1. To further localize the human Hyplip1 homolog and estimate its distance from the peak linkage markers, we fine-mapped the Hyplip1 locus and defined the borders of the region of conserved synteny between human and mouse. This involved establishing a physical map of a bacterial artificial chromosome (BAC) contig across the Hyplip1 locus and hybridizing a set of BACs to both human and mouse chromosomes by fluorescence in situ hybridization (FISH). We narrowed the location of the mouse Hyplip1 gene to a 1.5-cM region that is homologous only with human 1q21 and within approximately 5-10 Mb of the peak marker for linkage to FCHL. FCHL is a complex disorder and this distance may, thus, reflect the well-known problems hampering the mapping of complex disorders. Further studies identifying and sequencing the Hyplip1 gene will show whether the same gene predisposes to hyperlipidemia in human and mouse."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.org/dc/terms/identifier | "doi:10.1007/s003350010265"xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Chu M."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Xiao Q."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Lusis A.J."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Peltonen L."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Palotie A."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Castellani L.W."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Wessman M."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Sinsheimer J.S."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Pajukanta P."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Demant P."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Sallinen R."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Airaksinen T."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Bodnar J.S."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/author | "Sheth S.S."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/name | "Mamm Genome"xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/pages | "238-245"xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/title | "Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL."xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/11252174 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11252174 |
| http://purl.uniprot.org/citations/11252174 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11252174 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JE74-mappedCitation-11252174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11252174 |