| http://purl.uniprot.org/citations/11257006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11257006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11257006 | http://www.w3.org/2000/01/rdf-schema#comment | "Normal apoptosis occurs continuously in the olfactory neuroepithelium of adult vertebrates, making it a useful model for studying neuronal apoptosis. Here we demonstrate that overexpression of the anti-apoptotic Bag-1 gene in olfactory neuronal cells confers a strong resistance to apoptosis. Conversely decreased levels of Bag-1 were found to precede a massive wave of olfactory neuronal apoptosis triggered by synaptic target ablation. We show that the decrease is brought about by ubiquitination and subsequent degradation of the Bag-1 protein. The ring finger protein Siah-2 is a likely candidate for the ubiquitination reaction since Siah-2 mRNA accumulated in lesioned olfactory neuroepithelium and overexpression of Siah-2 stimulated Bag-1 ubiquitination and degradation in transient expression assays. These results together identify destabilization of Bag-1 as a necessary step in olfactory neuronal apoptosis."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.114.7.1409"xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.114.7.1409"xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Bowtell D.D.L."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Bowtell D.D.L."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Schneikert J."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Schneikert J."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Cato A.C.B."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Cato A.C.B."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Michel D."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Michel D."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Desbois C."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Desbois C."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Debure L."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Debure L."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Moyse E."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Moyse E."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Sourisseau T."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/author | "Sourisseau T."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/11257006 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |