| http://purl.uniprot.org/citations/11258796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11258796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11258796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11258796 | http://www.w3.org/2000/01/rdf-schema#comment | "Escherichia coli O157:H7 is a major food-borne infectious pathogen that causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Here we report the complete chromosome sequence of an O157:H7 strain isolated from the Sakai outbreak, and the results of genomic comparison with a benign laboratory strain, K-12 MG1655. The chromosome is 5.5 Mb in size, 859 Kb larger than that of K-12. We identified a 4.1-Mb sequence highly conserved between the two strains, which may represent the fundamental backbone of the E. coli chromosome. The remaining 1.4-Mb sequence comprises of O157:H7-specific sequences, most of which are horizontally transferred foreign DNAs. The predominant roles of bacteriophages in the emergence of O157:H7 is evident by the presence of 24 prophages and prophage-like elements that occupy more than half of the O157:H7-specific sequences. The O157:H7 chromosome encodes 1632 proteins and 20 tRNAs that are not present in K-12. Among these, at least 131 proteins are assumed to have virulence-related functions. Genome-wide codon usage analysis suggested that the O157:H7-specific tRNAs are involved in the efficient expression of the strain-specific genes. A complete set of the genes specific to O157:H7 presented here sheds new insight into the pathogenicity and the physiology of O157:H7, and will open a way to fully understand the molecular mechanisms underlying the O157:H7 infection."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.org/dc/terms/identifier | "doi:10.1093/dnares/8.1.11"xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.org/dc/terms/identifier | "doi:10.1093/dnares/8.1.11"xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.org/dc/terms/identifier | "doi:10.1093/dnares/8.1.11"xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Hattori M."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Hattori M."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Hattori M."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Takami H."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Takami H."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Takami H."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Yokoyama K."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Yokoyama K."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Yokoyama K."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Han C.-G."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Han C.-G."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Han C.-G."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Honda T."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Honda T."xsd:string |
| http://purl.uniprot.org/citations/11258796 | http://purl.uniprot.org/core/author | "Honda T."xsd:string |