| http://purl.uniprot.org/citations/11259588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11259588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11259588 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we investigate the role of the receptor-like protein tyrosine phosphatase CD148 in T-cell activation. Overexpression of CD148 in the Jurkat T-cell line inhibited activation of the transcription factor nuclear factor of activated T cells following T-cell receptor (TCR) stimulation but not following stimulation through a heterologously expressed G protein-coupled receptor, the human muscarinic receptor subtype 1. Using a tetracycline-inducible expression system, we show that the TCR-mediated activation of both the Ras and calcium pathways was inhibited by expression of CD148 at levels that approximate those found in activated primary T cells. These effects were dependent on the phosphatase activity of CD148. Analysis of TCR-induced protein tyrosine phosphorylation demonstrated that most phosphoproteins were unaffected by CD148 expression. However, phospholipase Cgamma1 (PLCgamma1) and LAT were strikingly hypophosphorylated in CD148-expressing cells following TCR stimulation, whereas the phosphorylation levels of Slp-76 and Itk were modestly reduced. Based on these results, we propose that CD148 negatively regulates TCR signaling by interfering with the phosphorylation and function of PLCgamma1 and LAT."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.21.7.2393-2403.2001"xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.21.7.2393-2403.2001"xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/author | "Majeti R."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/author | "Majeti R."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/author | "Baker J.E."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/author | "Baker J.E."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/author | "Tangye S.G."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/author | "Tangye S.G."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/pages | "2393-2403"xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/pages | "2393-2403"xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/title | "Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/title | "Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11259588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11259588 |
| http://purl.uniprot.org/citations/11259588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11259588 |