| http://purl.uniprot.org/citations/11264294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11264294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11264294 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel metalloproteinase with similarity to pregnancy-associated plasma protein-A (PAPP-A), which we denoted PAPP-A2, has been identified. Through expression in mammalian cells we showed that recombinant PAPP-A2 polypeptide of 1558 residues resulted from processing of a 1791-residue prepro-protein. Unlike PAPP-A, PAPP-A2 migrated as a monomer (of 220 kDa) in non-reducing SDS-polyacrylamide gel electrophoresis. The prepro-parts of PAPP-A2 and PAPP-A are not homologous, but mature PAPP-A2 shares 45% of its residues with PAPP-A. Because PAPP-A specifically cleaves insulin-like growth factor-binding protein (IGFBP)-4, one of six known modulators of IGF-I and -II, we looked for a possible PAPP-A2 substrate among the members of this family. We showed that PAPP-A2 specifically cleaved IGFBP-5 at one site, between Ser-143 and Lys-144. In contrast to the cleavage of IGFBP-4 by PAPP-A that strictly requires the presence of IGF, the cleavage of IGFBP-5 by PAPP-A2 was IGF-independent. Recent data firmly establish PAPP-A and IGFBP-4 as an important functional pair in several systems. Because of its close relationship with PAPP-A, both structurally and functionally, PAPP-A2 is a likely candidate IGFBP-5 proteinase in many tissues and conditioned media where IGFBP-5 proteolysis has been reported."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m102191200"xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m102191200"xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Sottrup-Jensen L."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Sottrup-Jensen L."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Oxvig C."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Oxvig C."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Overgaard M.T."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Overgaard M.T."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Conover C.A."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Conover C.A."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Boldt H.B."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Boldt H.B."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Laursen L.S."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/author | "Laursen L.S."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/pages | "21849-21853"xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/pages | "21849-21853"xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/title | "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase."xsd:string |
| http://purl.uniprot.org/citations/11264294 | http://purl.uniprot.org/core/title | "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase."xsd:string |