| http://purl.uniprot.org/citations/11266473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11266473 | http://www.w3.org/2000/01/rdf-schema#comment | "Because mutations in Rab27a have been linked to immune defects in humans, we have examined cytotoxic lymphocyte function in ashen mice, which contain a splicing mutation in Rab27a. Ashen cytotoxic T lymphocytes (CTLs) showed a >90% reduction in lytic activity on Fas-negative target cells compared with control C3H CTLs, and ashen natural killer cell activity was likewise diminished. Although their granule-mediated cytotoxicity pathway is profoundly defective, ashen CTLs displayed a normal FasL-Fas cytotoxicity pathway. The CD4/8 phenotype of ashen T cells and their proliferative responses were similar to controls. Ashen CTLs had normal levels of perforin and granzymes A and B and normal-appearing perforin-positive granules, which polarized upon interaction of the CTLs with anti-CD3-coated beads. However, rapid anti-CD3-induced granule secretion was drastically defective in both CD8(+) and CD4(+) T cells from ashen mice. This defect in exocytosis was not observed in the constitutive pathway, as T cell receptor-stimulated interferon-gamma secretion was normal. Based on these results and our demonstration that Rab27a colocalizes with granzyme B-positive granules and is undetectable in ashen CTLs, we conclude that Rab27a is required for a late step in granule exocytosis, compatible with current models of Rab protein function in vesicle docking and fusion."xsd:string |
| http://purl.uniprot.org/citations/11266473 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.152.4.835"xsd:string |
| http://purl.uniprot.org/citations/11266473 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/11266473 | http://purl.uniprot.org/core/author | "Hammer J.A."xsd:string |
| http://purl.uniprot.org/citations/11266473 | http://purl.uniprot.org/core/author | "Henkart P.A."xsd:string |
| http://purl.uniprot.org/citations/11266473 | http://purl.uniprot.org/core/author | "Haddad E.K."xsd:string |
| http://purl.uniprot.org/citations/11266473 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11266473 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/11266473 | http://purl.uniprot.org/core/pages | "835-842"xsd:string |
| http://purl.uniprot.org/citations/11266473 | http://purl.uniprot.org/core/title | "Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice."xsd:string |
| http://purl.uniprot.org/citations/11266473 | http://purl.uniprot.org/core/volume | "152"xsd:string |
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