| http://purl.uniprot.org/citations/11266503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11266503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11266503 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteins belonging to the 14--3-3 family interact with various regulatory proteins involved in cellular signaling, cell cycle regulation, or apoptosis. 14--3-3 proteins have been suggested to act by regulating the cytoplasmic/nuclear localization of their target proteins or by acting as molecular scaffolds or chaperones. We have previously shown that overexpression of 14--3-3 enhances the transcriptional activity of the glucocorticoid receptor (GR), which is a member of the nuclear receptor family. In this study, we show that 14--3-3 interacts with the nuclear receptor corepressor RIP140. In transfection assays, RIP140 antagonizes 14--3-3-enhanced GR transactivation. Using colocalization studies we demonstrate that 14--3-3 can export RIP140 out of the nucleus and, interestingly, can also change its intranuclear localization. Moreover, we also observed that 14--3-3 can bind various other nuclear receptors and cofactors. In summary, our findings suggest that 14--3-3-mediated intracellular relocalization of the GR corepressor RIP140 might be a novel mechanism to enhance glucocorticoid responsiveness of target genes. They furthermore indicate a more general role for 14--3-3 protein by influencing the nuclear availability of nuclear receptor-associated cofactors."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.org/dc/terms/identifier | "doi:10.1210/mend.15.4.0624"xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.org/dc/terms/identifier | "doi:10.1210/mend.15.4.0624"xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Gustafsson J.-A."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Gustafsson J.-A."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Holter E."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Holter E."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Tazawa H."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Tazawa H."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Treuter E."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Treuter E."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Wakui H."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Wakui H."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Zilliacus J."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/author | "Zilliacus J."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/name | "Mol. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/name | "Mol. Endocrinol."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/pages | "501-511"xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/pages | "501-511"xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/title | "Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140."xsd:string |
| http://purl.uniprot.org/citations/11266503 | http://purl.uniprot.org/core/title | "Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140."xsd:string |