| http://purl.uniprot.org/citations/11266540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11266540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11266540 | http://www.w3.org/2000/01/rdf-schema#comment | "Tcf/Lef family transcription factors are the downstream effectors of the Wingless/Wnt signal transduction pathway. Upon Wingless/Wnt signalling, beta-catenin translocates to the nucleus, interacts with Tcf (1-3) and thus activates transcription of target genes (4,5). Tcf factors also interact with members of the Groucho (Grg/TLE) family of transcriptional co-repressors (6). We have now tested all known mammalian Groucho family members for their ability to interact specifically with individual Tcf/Lef family members. Transcriptional activation by any Tcf could be repressed by Grg-1, Grg-2/TLE-2, Grg-3 and Grg-4 in a reporter assay. Specific interactions between Tcf and Grg proteins may be achieved in vivo by tissue- or cell type-limited expression. To address this, we determined the expression of all Tcf and Grg/TLE family members in a panel of cell lines. Within any cell line, several Tcfs and TLEs are co-expressed. Thus, redundancy in Tcf/Grg interactions appears to be the rule. The 'long' Groucho family members containing five domains are repressors of Tcf-mediated transactivation, whereas Grg-5, which only contains the first two domains, acts as a de-repressor. As previously shown for Drosophila Groucho, we show that long Grg proteins interact with histone deacetylase-1. Although Grg-5 contains the GP homology domain that mediates HDAC binding in long Grg proteins, Grg-5 fails to bind this co-repressor, explaining how it can de-repress transcription."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/29.7.1410"xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/29.7.1410"xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/author | "Clevers H."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/author | "Clevers H."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/author | "Brantjes H."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/author | "Brantjes H."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/author | "Roose J."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/author | "Roose J."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/author | "van De Wetering M."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/author | "van De Wetering M."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/pages | "1410-1419"xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/pages | "1410-1419"xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/title | "All Tcf HMG box transcription factors interact with Groucho-related co-repressors."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/title | "All Tcf HMG box transcription factors interact with Groucho-related co-repressors."xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/11266540 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11266540 |
| http://purl.uniprot.org/citations/11266540 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11266540 |