http://purl.uniprot.org/citations/11274061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11274061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11274061 | http://www.w3.org/2000/01/rdf-schema#comment | "An in vitro system that recapitulates the in vivo effect of AU-rich elements (AREs) on mRNA deadenylation has been developed from Xenopus activated egg extracts. ARE-mediated deadenylation is uncoupled from mRNA body decay, and the rate of deadenylation increases with the number of tandem AUUUAs. A novel ARE-binding protein called ePAB (for embryonic poly(A)-binding protein) has been purified from this extract by ARE affinity selection. ePAB exhibits 72% identity to mammalian and Xenopus PABP1 and is the predominant poly(A)-binding protein expressed in the stage VI oocyte and during Xenopus early development. Immunodepletion of ePAB increases the rate of both ARE-mediated and default deadenylation in vitro. In contrast, addition of even a small excess of ePAB inhibits deadenylation, demonstrating that the ePAB concentration is critical for determining the rate of ARE-mediated deadenylation. These data argue that ePAB is the poly(A)-binding protein responsible for stabilization of poly(A) tails and is thus a potential regulator of mRNA deadenylation and translation during early development."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.872201"xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.872201"xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/author | "Standart N."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/author | "Standart N."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/author | "Steitz J.A."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/author | "Steitz J.A."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/author | "Voeltz G.K."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/author | "Voeltz G.K."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/author | "Ongkasuwan J."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/author | "Ongkasuwan J."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/pages | "774-788"xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/pages | "774-788"xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/title | "A novel embryonic poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg extracts."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/title | "A novel embryonic poly(A) binding protein, ePAB, regulates mRNA deadenylation in Xenopus egg extracts."xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/volume | "15"xsd:string |
http://purl.uniprot.org/citations/11274061 | http://purl.uniprot.org/core/volume | "15"xsd:string |
http://purl.uniprot.org/citations/11274061 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11274061 |
http://purl.uniprot.org/citations/11274061 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11274061 |